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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN12
All Species:
16.67
Human Site:
S476
Identified Species:
36.67
UniProt:
Q05209
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05209
NP_001124480.1
780
88120
S476
P
C
I
A
D
K
I
S
K
P
Q
E
L
S
S
Chimpanzee
Pan troglodytes
XP_519168
792
88529
S488
P
C
I
T
D
K
I
S
K
P
Q
E
L
S
S
Rhesus Macaque
Macaca mulatta
XP_001082837
733
82786
S435
K
K
L
E
R
N
L
S
F
E
I
K
K
V
P
Dog
Lupus familis
XP_540396
757
85032
S451
P
C
I
S
D
K
I
S
K
L
Q
E
L
S
S
Cat
Felis silvestris
Mouse
Mus musculus
P35831
775
86973
S475
S
S
V
V
D
R
T
S
K
P
Q
E
L
S
A
Rat
Rattus norvegicus
NP_476456
766
85965
S468
I
K
I
K
S
A
S
S
S
V
V
D
K
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507461
747
83881
L448
K
S
V
P
P
N
V
L
D
K
T
S
K
P
Q
Chicken
Gallus gallus
XP_415970
1211
131521
F897
S
S
V
T
D
K
N
F
K
S
Q
E
Q
I
S
Frog
Xenopus laevis
NP_001084841
660
74123
L362
S
H
P
V
P
P
I
L
T
P
S
P
P
S
A
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
S272
E
M
R
T
Q
R
H
S
A
V
Q
T
K
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
S509
D
V
N
A
K
P
V
S
E
K
T
G
N
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
91.4
88
N.A.
82.8
83.5
N.A.
74.6
48.3
58.2
46.7
N.A.
N.A.
N.A.
N.A.
28.9
Protein Similarity:
100
95.4
92.3
91
N.A.
88.3
88.8
N.A.
81.1
53.5
66.9
57.4
N.A.
N.A.
N.A.
N.A.
44
P-Site Identity:
100
93.3
6.6
86.6
N.A.
53.3
26.6
N.A.
0
40
20
13.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
93.3
26.6
93.3
N.A.
73.3
33.3
N.A.
13.3
46.6
26.6
20
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
19
0
10
0
0
10
0
0
0
0
0
19
% A
% Cys:
0
28
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
46
0
0
0
10
0
0
10
0
0
0
% D
% Glu:
10
0
0
10
0
0
0
0
10
10
0
46
0
10
10
% E
% Phe:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
0
% G
% His:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
37
0
0
0
37
0
0
0
10
0
0
10
0
% I
% Lys:
19
19
0
10
10
37
0
0
46
19
0
10
37
0
0
% K
% Leu:
0
0
10
0
0
0
10
19
0
10
0
0
37
0
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
19
10
0
0
0
0
0
10
0
0
% N
% Pro:
28
0
10
10
19
19
0
0
0
37
0
10
10
10
10
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
55
0
10
0
19
% Q
% Arg:
0
0
10
0
10
19
0
0
0
0
0
0
0
0
0
% R
% Ser:
28
28
0
10
10
0
10
73
10
10
10
10
0
55
46
% S
% Thr:
0
0
0
28
0
0
10
0
10
0
19
10
0
0
0
% T
% Val:
0
10
28
19
0
0
19
0
0
19
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _